The granddaughter of silent film star John Barrymore, Drew is a dedicated philanthropist and regularly donates her time and resources to charities such as the Elizabeth Glaser Pediatric AIDS Foundation and the Wildlife Waystation, an organization that rescues and offers sanctuary to animals from around the world.

Drew landed a feature role in Steven Spielberg's E.T. The Extraterrestrial when she was 6 years old. Later she starred in such films as Firestarter, Boys on the Side, Mad Love, Batman Forever, The Wedding Singer, Everyone Says I Love You, and Scream. She also received a Golden Globe nomination for her performance in Gun Crazy. Most recently Drew starred in Charlie's Angels, a film that was produced by her own production company, Flower Films.

She has had two brief marriages, the most recent to MTV comic Tom Green. Drew's a complex character who openly admits to loving men and women. The popular actress once told an interviewer,

"Do I like women? I like women. Do I like them sexually? Yeah, I do. Totally. To the extent of how I fool around with them, I think that when I was younger I was with a lot of women. I used to love to be with a woman. I haven't been with a woman in a long time."